{"id":1488,"date":"2017-01-25T14:50:31","date_gmt":"2017-01-25T13:50:31","guid":{"rendered":"http:\/\/www.alpha1-deutschland.org\/?page_id=1488"},"modified":"2026-08-17T19:01:44","modified_gmt":"2026-08-17T17:01:44","slug":"forschung-studien","status":"publish","type":"page","link":"https:\/\/alpha1-deutschland.org\/en\/forschung-studien","title":{"rendered":"Research &amp; Studies"},"content":{"rendered":"<div id=\"fws_6a8f065e6017d\"  data-column-margin=\"default\" data-midnight=\"dark\" data-top-percent=\"2%\"  class=\"wpb_row vc_row-fluid vc_row full-width-section\"  style=\"padding-top: calc(100vw * 0.02); padding-bottom: 0px; \"><div class=\"row-bg-wrap\" data-bg-animation=\"none\" data-bg-animation-delay=\"\" data-bg-overlay=\"false\"><div class=\"inner-wrap row-bg-layer\" ><div class=\"row-bg viewport-desktop\"  style=\"\"><\/div><\/div><\/div><div class=\"row_col_wrap_12 col span_12 dark left\">\n\t<div  class=\"vc_col-sm-2 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n\n\t<div  class=\"vc_col-sm-8 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t\n<div class=\"wpb_text_column wpb_content_element\" >\n\t<div class=\"cmsms_text fadeInUp animated\" data-animation=\"fadeInUp\" data-delay=\"0\">\n<h1><span style=\"color: #004267;\">Research and studies<\/span><\/h1>\n<\/div>\n<div class=\"cmsms_text fadeInUp animated\" data-animation=\"fadeInUp\" data-delay=\"0\">\n<p style=\"font-weight: 400;\">An overview of all ongoing clinical trials in the EU is now available on a website of the European Medicines Agency (EMA), in all European languages. The German page can be accessed at [link to German page]. <a href=\"https:\/\/euclinicaltrials.eu\/search-for-clinical-trials\/?lang=de\">https:\/\/euclinicaltrials.eu\/search-for-clinical-trials\/?lang=de<\/a>. In the search field that appears, you must enter the disease of interest (e.g., alpha-1 antitrypsin) and start the search. All ongoing studies will then be displayed (unfortunately, these are not yet translated into German). By clicking on the relevant studies, you will be taken to pages containing all the relevant information. If you are interested in participating, you should first check whether patients are being recruited in Germany at all, and then whether you meet all the inclusion criteria and none of the exclusion criteria. If all these criteria apply, you can express your interest in participating by email to a study center. Independent of this EMA website, Alpha1 Germany will continue to provide information about the most important studies here in the form of short articles.<\/p>\n<p>A more elegant way to access the list of studies than the keyword search described above is offered by the tool provided by the EMA. <a href=\"https:\/\/euclinicaltrials.eu\/search-for-clinical-trials\/trial-map\"><b><u>interactive map of Europe<\/u><\/b>.<\/a><\/p>\n<p style=\"font-weight: 400;\">An even simpler (because it is already organized by disease) and also partially German-language access to clinical trials is offered <a href=\"https:\/\/klinischestudien.de\/\">https:\/\/klinischestudien.de<\/a>. Please note that the link to register for a clinical trial leads to the operator of the website, not to the study center of the study in question!<\/p>\n<p>Here you will find many more calls for studies:<\/p>\n<p>To the search mask of <a href=\"https:\/\/clinicaltrials.gov\/\">National Library of Medicine<\/a>.<\/p>\n<p>Current studies of <a href=\"https:\/\/www.thoraxklinik-heidelberg.de\/forschung\/pneumologisches-studienzentrum\/pneumologisches-studienzentrum\">Thorax Clinic Heidelberg<\/a> for COPD.<\/p>\n<h3>A notice:<\/h3>\n<p>Many of the scientific texts and links are in English. Therefore, we can offer you the following translation aid:\u00a0<a href=\"https:\/\/www.deepl.com\/translator\" target=\"_blank\" rel=\"noopener noreferrer\">Free translator from DEEPL<\/a>\u00a0I highly recommend it.<\/p>\n<p>Below you will find the latest articles from the &#039;Research and Studies&#039; section. The reports and calls for participation in clinical trials are for informational purposes only and do not constitute a recommendation to participate.<\/p>\n<p>Reports and calls for participation in clinical trials are for informational purposes only and do not constitute a recommendation to participate. If you have any questions about participating, always consult your doctor or another qualified healthcare professional before making your personal decision.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n\n\n\n\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n\n\t<div  class=\"vc_col-sm-2 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n<\/div><\/div>\n\t\t<div id=\"fws_6a8f065e622b9\"  data-column-margin=\"default\" data-midnight=\"dark\" data-top-percent=\"2%\"  class=\"wpb_row vc_row-fluid vc_row full-width-section\"  style=\"padding-top: calc(100vw * 0.02); padding-bottom: 0px; \"><div class=\"row-bg-wrap\" data-bg-animation=\"none\" data-bg-animation-delay=\"\" data-bg-overlay=\"false\"><div class=\"inner-wrap row-bg-layer\" ><div class=\"row-bg viewport-desktop\"  style=\"\"><\/div><\/div><\/div><div class=\"row_col_wrap_12 col span_12 dark left\">\n\t<div  class=\"vc_col-sm-12 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t<div class='nectar-post-grid-wrap text-color-light spacing-15px' data-el-settings='{\"post_type\":\"post\",\"pagination\":\"load-more\",\"image_size\":\"large\",\"parallax_scrolling\":\"\",\"aspect_ratio_image_size\":\"\",\"category_position\":\"default\",\"category_display\":\"default\",\"display_categories\":\"0\",\"display_excerpt\":\"0\",\"excerpt_length\":\"20\",\"content_next_to_image_excerpt_pos\":\"default\",\"display_date\":\"yes\",\"display_estimated_reading_time\":\"0\",\"display_author\":\"0\",\"author_functionality\":\"default\",\"author_position\":\"default\",\"color_overlay\":\"\",\"color_overlay_opacity\":\"0.3\",\"color_overlay_hover_opacity\":\"0.4\",\"card_bg_color\":\"\",\"grid_style\":\"content_overlaid\",\"hover_effect\":\"zoom\",\"post_title_overlay\":\"\",\"heading_tag\":\"default\",\"heading_tag_render\":\"default\",\"enable_gallery_lightbox\":\"0\",\"remove_links\":\"0\",\"category_style\":\"underline\",\"overlay_secondary_project_image\":\"\",\"vertical_list_hover_effect\":\"none\",\"vertical_list_read_more\":\"\",\"vertical_list_read_more_style\":\"text\",\"read_more_button\":\"0\",\"animation\":\"none\",\"custom_fields\":\"\",\"custom_fields_location\":\"before_post_meta\",\"display_type\":\"grid\",\"text_content_layout\":\"all_top_left\"}' data-style='content_overlaid' data-query='{\"post_type\":\"post\",\"posts_per_page\":\"5\",\"order\":\"DESC\",\"orderby\":\"date\",\"offset\":\"0\",\"cpt_name\":\"post\",\"custom_query_tax\":\"\",\"ignore_sticky_posts\":\"\",\"exclude_current_post\":\"\"}' data-load-more-color='extra-color-1' data-load-more-text='Load More'><div class=\"nectar-post-grid-filters\" data-active-color=\"default\" data-align=\"default\" data-animation=\"none\" data-sortable=\"\"><div><a href=\"#\" data-filter=\"forschung-und-studien\" data-total-count=\"24\">Research and studies<\/a><\/div><\/div><div class=\"nectar-post-grid text-opacity-1 text-opacity-hover-1 category-position-before-title\" data-indicator=\"\" data-indicator-style=\"default\" data-indicator-text-color=\"#fff\" data-indicator-color=\"#000\" data-indicator-text=\"View\" data-masonry=\"yes\" data-columns=\"3\" data-hover-effect=\"zoom\" data-text-style=\"default\" data-border-radius=\"none\" data-grid-item-height=\"30vh\" data-grid-spacing=\"15px\" data-text-layout=\"all_top_left\" data-text-color=\"light\" data-text-hover-color=\"light\" data-shadow-hover=\"\" data-animation=\"none\" data-animation-stagger=\"90\" data-cat-click=\"default\" ><div class=\"nectar-post-grid-item\" data-post-id=\"7131\" data-has-img=\"true\"> <div class=\"inner\"><div class=\"nectar-post-grid-item-bg-wrap\"><div class=\"nectar-post-grid-item-bg-wrap-inner\"><div class=\"nectar-post-grid-item-bg\"><img loading=\"lazy\" decoding=\"async\" class=\"nectar-lazy skip-lazy nectar-post-grid-item-bg__media\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201920%201080'%2F%3E\" alt=\"Vier m\u00e4nnliche Personen stehen auf einer B\u00fchne und empfangen einen Preis.\" height=\"1080\" width=\"1920\" data-nectar-img-src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/neu-forschung-zu-alpha1-foerderpreis-2025-1024x576.jpg\" data-nectar-img-srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/neu-forschung-zu-alpha1-foerderpreis-2025-1024x576.jpg 1024w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/neu-forschung-zu-alpha1-foerderpreis-2025-300x169.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/neu-forschung-zu-alpha1-foerderpreis-2025-768x432.jpg 768w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/neu-forschung-zu-alpha1-foerderpreis-2025-1536x864.jpg 1536w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/neu-forschung-zu-alpha1-foerderpreis-2025.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><\/div><div class=\"bg-overlay\"  data-opacity=\"0.3\" data-hover-opacity=\"0.4\"><\/div><div class=\"content\"><a class=\"nectar-post-grid-link\" href=\"https:\/\/alpha1-deutschland.org\/en\/foerderpreis-2025\" ><span class=\"screen-reader-text\">New research on Alpha-1: Congratulations to Dr. Andreas Hoheisel for the 2025 research award!<\/span><\/a><div class=\"item-main\"><h3 class=\"post-heading\"><span>New research on Alpha-1: Congratulations to Dr. Andreas Hoheisel for the 2025 research award!<\/span><\/h3><span class=\"nectar-post-grid-item__meta-wrap\"><span class=\"meta-date\">November 18, 2025<\/span><\/span><\/div><\/div><\/div><\/div><div class=\"nectar-post-grid-item\" data-post-id=\"7081\" data-has-img=\"true\"> <div class=\"inner\"><div class=\"nectar-post-grid-item-bg-wrap\"><div class=\"nectar-post-grid-item-bg-wrap-inner\"><div class=\"nectar-post-grid-item-bg\"><img loading=\"lazy\" decoding=\"async\" class=\"nectar-lazy skip-lazy nectar-post-grid-item-bg__media\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201920%201080'%2F%3E\" alt=\"A person holds a tablet displaying a presentation titled &quot;DNA and RNA Edition&quot; by Marina Bouscharain, with logos of CNRS, Inserm, Universit\u00e9 de Bordeaux, and BRIC visible.\" height=\"1080\" width=\"1920\" data-nectar-img-src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/shutterstock_2495079583-1024x576.jpg\" data-nectar-img-srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/shutterstock_2495079583-1024x576.jpg 1024w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/shutterstock_2495079583-300x169.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/shutterstock_2495079583-768x432.jpg 768w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/shutterstock_2495079583-1536x864.jpg 1536w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/shutterstock_2495079583.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><\/div><div class=\"bg-overlay\"  data-opacity=\"0.3\" data-hover-opacity=\"0.4\"><\/div><div class=\"content\"><a class=\"nectar-post-grid-link\" href=\"https:\/\/alpha1-deutschland.org\/en\/dna-rna-therapien\" ><span class=\"screen-reader-text\">DNA and RNA interventions for the treatment of alpha-1 antitrypsin deficiency<\/span><\/a><div class=\"item-main\"><h3 class=\"post-heading\"><span>DNA and RNA interventions for the treatment of alpha-1 antitrypsin deficiency<\/span><\/h3><span class=\"nectar-post-grid-item__meta-wrap\"><span class=\"meta-date\">November 18, 2025<\/span><\/span><\/div><\/div><\/div><\/div><div class=\"nectar-post-grid-item\" data-post-id=\"6915\" data-has-img=\"true\"> <div class=\"inner\"><div class=\"nectar-post-grid-item-bg-wrap\"><div class=\"nectar-post-grid-item-bg-wrap-inner\"><div class=\"nectar-post-grid-item-bg\"><img loading=\"lazy\" decoding=\"async\" class=\"nectar-lazy skip-lazy nectar-post-grid-item-bg__media\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%20900%20400'%2F%3E\" alt=\"CALM-QE Multidimensionale Asthma &amp; COPD Forschungsmodelle basierend auf KI sowie Machine Learning\" height=\"400\" width=\"900\" data-nectar-img-src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/calm-qe-fuer-asthma-und-copd.jpg\" data-nectar-img-srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/calm-qe-fuer-asthma-und-copd.jpg 900w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/calm-qe-fuer-asthma-und-copd-300x133.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/calm-qe-fuer-asthma-und-copd-768x341.jpg 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/div><\/div><\/div><div class=\"bg-overlay\"  data-opacity=\"0.3\" data-hover-opacity=\"0.4\"><\/div><div class=\"content\"><a class=\"nectar-post-grid-link\" href=\"https:\/\/alpha1-deutschland.org\/en\/calm%e2%80%91qe\" ><span class=\"screen-reader-text\">CALM\u2011QE \u2013 Artificial intelligence for a better understanding of asthma and COPD<\/span><\/a><div class=\"item-main\"><h3 class=\"post-heading\"><span>CALM\u2011QE \u2013 Artificial intelligence for a better understanding of asthma and COPD<\/span><\/h3><span class=\"nectar-post-grid-item__meta-wrap\"><span class=\"meta-date\">September 22, 2025<\/span><\/span><\/div><\/div><\/div><\/div><div class=\"nectar-post-grid-item\" data-post-id=\"6911\" data-has-img=\"true\"> <div class=\"inner\"><div class=\"nectar-post-grid-item-bg-wrap\"><div class=\"nectar-post-grid-item-bg-wrap-inner\"><div class=\"nectar-post-grid-item-bg\"><img loading=\"lazy\" decoding=\"async\" class=\"nectar-lazy skip-lazy nectar-post-grid-item-bg__media\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%20900%20400'%2F%3E\" alt=\"\" height=\"400\" width=\"900\" data-nectar-img-src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/permed-copd-studie.jpg\" data-nectar-img-srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/permed-copd-studie.jpg 900w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/permed-copd-studie-300x133.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/permed-copd-studie-768x341.jpg 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/div><\/div><\/div><div class=\"bg-overlay\"  data-opacity=\"0.3\" data-hover-opacity=\"0.4\"><\/div><div class=\"content\"><a class=\"nectar-post-grid-link\" href=\"https:\/\/alpha1-deutschland.org\/en\/permed-copd\" ><span class=\"screen-reader-text\">PerMed-COPD \u2013 Patients at the Center of Research<\/span><\/a><div class=\"item-main\"><h3 class=\"post-heading\"><span>PerMed-COPD \u2013 Patients at the Center of Research<\/span><\/h3><span class=\"nectar-post-grid-item__meta-wrap\"><span class=\"meta-date\">September 22, 2025<\/span><\/span><\/div><\/div><\/div><\/div><div class=\"nectar-post-grid-item\" data-post-id=\"6908\" data-has-img=\"true\"> <div class=\"inner\"><div class=\"nectar-post-grid-item-bg-wrap\"><div class=\"nectar-post-grid-item-bg-wrap-inner\"><div class=\"nectar-post-grid-item-bg\"><img loading=\"lazy\" decoding=\"async\" class=\"nectar-lazy skip-lazy nectar-post-grid-item-bg__media\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%20900%20400'%2F%3E\" alt=\"Mit dem PROM Projekt soll ein Fragebogen f\u00fcr Alpha-1 Betroffene entwickelt werden, der die Lebensqualit\u00e4t realistisch erfasst.\" height=\"400\" width=\"900\" data-nectar-img-src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/patientenfragebogen-bei-alpha-1-PROM.jpg\" data-nectar-img-srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/patientenfragebogen-bei-alpha-1-PROM.jpg 900w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/patientenfragebogen-bei-alpha-1-PROM-300x133.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/patientenfragebogen-bei-alpha-1-PROM-768x341.jpg 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/div><\/div><\/div><div class=\"bg-overlay\"  data-opacity=\"0.3\" data-hover-opacity=\"0.4\"><\/div><div class=\"content\"><a class=\"nectar-post-grid-link\" href=\"https:\/\/alpha1-deutschland.org\/en\/alpha-patientenfragebogen\" ><span class=\"screen-reader-text\">ALPHA \u2013 The new patient questionnaire for assessing quality of life in alpha-1 antitrypsin deficiency<\/span><\/a><div class=\"item-main\"><h3 class=\"post-heading\"><span>ALPHA \u2013 The new patient questionnaire for assessing quality of life in alpha-1 antitrypsin deficiency<\/span><\/h3><span class=\"nectar-post-grid-item__meta-wrap\"><span class=\"meta-date\">September 22, 2025<\/span><\/span><\/div><\/div><\/div><\/div><\/div><\/div>\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n<\/div><\/div>\n\t\t<div id=\"fws_6a8f065e6b903\"  data-column-margin=\"default\" data-midnight=\"dark\" data-top-percent=\"5%\" data-bottom-percent=\"5%\"  class=\"wpb_row vc_row-fluid vc_row full-width-section has-row-bg-color\"  style=\"padding-top: calc(100vw * 0.05); padding-bottom: calc(100vw * 0.05); --row-bg-color: #ffffff;\"><div class=\"row-bg-wrap\" data-bg-animation=\"none\" data-bg-animation-delay=\"\" data-bg-overlay=\"false\"><div class=\"inner-wrap row-bg-layer\" ><div class=\"row-bg viewport-desktop using-bg-color\"  style=\"background-color: #ffffff; \"><\/div><\/div><\/div><div class=\"row_col_wrap_12 col span_12 dark left\">\n\t<div  class=\"vc_col-sm-12 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t\n\t<div class=\"wpb_content_element\" data-interval=\"0\">\n\t\t<div class=\"wpb_wrapper tabbed clearfix\" data-style=\"material\" data-animation=\"fade\" data-spacing=\"default\" data-icon-size=\"32\" data-full-width-line=\"\" data-color-scheme=\"accent-color\" data-alignment=\"center\">\n\t\t\t<ul class=\"wpb_tabs_nav ui-tabs-nav clearfix\" role=\"tablist\"><li class=\"tab-item active-tab\"><a role=\"tab\" id=\"tab-title-aufruf-zu-studien\" href=\"#tab-aufruf-zu-studien\" aria-selected=\"true\" tabindex=\"0\" aria-controls=\"tab-aufruf-zu-studien\" class=\"active-tab\"><span>Call for studies<\/span><\/a><\/li><li class=\"tab-item\"><a role=\"tab\" id=\"tab-title-durchgefuehrte-studien\" href=\"#tab-durchgefuehrte-studien\" aria-selected=\"false\" tabindex=\"-1\" aria-controls=\"tab-durchgefuehrte-studien\" ><span>Studies conducted<\/span><\/a><\/li><li class=\"tab-item\"><a role=\"tab\" id=\"tab-title-unterstuetzung-von-forschungen\" href=\"#tab-unterstuetzung-von-forschungen\" aria-selected=\"false\" tabindex=\"-1\" aria-controls=\"tab-unterstuetzung-von-forschungen\" ><span>Support for research<\/span><\/a><\/li><li class=\"tab-item\"><a role=\"tab\" id=\"tab-title-umfragen\" href=\"#tab-umfragen\" aria-selected=\"false\" tabindex=\"-1\" aria-controls=\"tab-umfragen\" ><span>Surveys<\/span><\/a><\/li><li class=\"tab-item\"><a role=\"tab\" id=\"tab-title-publikationen\" href=\"#tab-publikationen\" aria-selected=\"false\" tabindex=\"-1\" aria-controls=\"tab-publikationen\" ><span>Publications<\/span><\/a><\/li><\/ul>\n\n\t\t\t\n\t\t\t<div id=\"tab-aufruf-zu-studien\" role=\"tabpanel\" aria-labelledby=\"tab-title-aufruf-zu-studien\" tabindex=\"0\" data-tab-icon=\"iconsmind-Information\" class=\"wpb_tab ui-tabs-panel wpb_ui-tabs-hide clearfix\"><span class=\"im-icon-wrap tab-icon\"><span><svg role=\"presentation\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\">\n        <path d=\"M18.007 24.028h-4c-0.368 0-0.667-0.3-0.667-0.667v-9.333c0-0.367 0.299-0.667 0.667-0.667h4c0.368 0 0.667 0.3 0.667 0.667v9.333c0 0.368-0.299 0.667-0.667 0.667zM14.673 22.695h2.667v-8h-2.667v8zM16.007 12.073c-1.475 0-2.675-1.197-2.675-2.675s1.2-2.675 2.675-2.675c1.475 0 2.675 1.197 2.675 2.675s-1.2 2.675-2.675 2.675zM16.007 8.057c-0.74 0-1.341 0.601-1.341 1.341s0.601 1.341 1.341 1.341c0.741 0 1.341-0.601 1.341-1.341s-0.6-1.341-1.341-1.341zM16 32c-8.823 0-16-7.177-16-16s7.177-16 16-16 16 7.177 16 16-7.177 16-16 16zM16 1.333c-8.087 0-14.667 6.583-14.667 14.667 0 8.087 6.58 14.667 14.667 14.667 8.085 0 14.667-6.58 14.667-14.667 0-8.085-6.579-14.667-14.667-14.667z\"><\/path>\n        <\/svg><\/span><\/span>\n\t\t\t\t<div id=\"fws_6a8f065e6d6af\" data-midnight=\"\" data-column-margin=\"90px\" class=\"wpb_row vc_row-fluid vc_row inner_row vc_row-o-equal-height vc_row-flex vc_row-o-content-middle\"  style=\"padding-top: 3%; padding-bottom: 3%; \"><div class=\"row-bg-wrap\"> <div class=\"row-bg\" ><\/div> <\/div><div class=\"row_col_wrap_12_inner col span_12  left\">\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"nectar-fancy-ul\" data-list-icon=\"fa fa-check\" data-animation=\"false\" data-animation-delay=\"0\" data-color=\"accent-color\" data-spacing=\"10px\" data-alignment=\"left\"> \n<div class=\"field field--name-field-nir-news-title field--type-string field--label-hidden\">\n<p>&nbsp;<\/p>\n<ul>\n<li>WAVE Life Science has presented the first, very encouraging results of the Phase 1 and 2 clinical trials announced below, as <a href=\"https:\/\/ir.wavelifesciences.com\/news-releases\/news-release-details\/wave-life-sciences-announces-positive-update-ongoing\" target=\"_blank\" rel=\"noopener\">Press release<\/a> and in great detail within the framework of <a href=\"https:\/\/ir.wavelifesciences.com\/static-files\/bbf2be84-24dc-4706-b840-7d4fdb827a30\" target=\"_blank\" rel=\"noopener\">Investors conference<\/a>. According to the report, an RNA-based intervention administered via subcutaneous injections has successfully stimulated the production of healthy M-AATs and reduced the production of the clumping-prone Z-AAT in patients with ZZ. This should improve lung protection and help clear liver deposits. No concerning side effects have been observed to date. In one participant who developed an infection unrelated to the trial medication, it was demonstrated that the release of healthy M-AATs increased as expected and desired during the inflammatory phase.<\/li>\n<li><a href=\"https:\/\/alpha1-deutschland.org\/en\/studienteilnahme-zur-untersuchung-psychischer-belastungen-und-der-lebensqualitaet-bei-personen-mit-copd-infolge-eines-alpha-1-antitrypsin-mangels-aatd\/\">Participation in a study investigating psychological stress and quality of life in individuals with COPD due to alpha-1 antitrypsin deficiency (AATD)<\/a><\/li>\n<li>After the successful completion of the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9931494\/\">first COSYCONET study<\/a> There is now a follow-up study called COSYCONET-2, which also addresses the effects of COPD (including in patients with alpha-1 antitrypsin deficiency). Further information and participation requirements can be found [here\/on the website]. <a href=\"http:\/\/www.asconet.net\/html\/cosyconet-2\">here<\/a>:<\/li>\n<li class=\"field__item\">Wave Life Sciences announces the approval of the first clinical trial application for the RestorAATion-2 study of WVE-006 in individuals with Alpha-1 Antitrypsin Deficiency (AATD).<br \/>\nRestorAATion-2 is an open-label, phase 1b\/2a study to evaluate the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of WVE-006 in individuals with AATD who have the homozygous Pi*ZZ mutation.<br \/>\n<b>Currently (as of mid-2025), participants are also being recruited in Germany for this clinical trial.<\/b><br \/>\nYou can find more information here. <a href=\"https:\/\/wavelifesciences.com\/pipeline\/lead-programs\/\" target=\"_blank\" rel=\"noopener\">here.<\/a><\/li>\n<\/ul>\n<\/div>\n<ul>\n<li>The Arrowhead Pharmaceuticals study mentioned further down in this compilation is entering its next phase: after the long-established Japanese pharmaceutical company Takeda acquired the rights to the liver medication Fazirsiran and renamed the active ingredient TAK-999, the pool of potential participants for the Phase 3 drug trial is now being significantly expanded. In Germany, participation in this study, named Redwood, will be possible at three different clinical sites. Further details about the study and, in particular, the opportunities for participation can be found [here\/on the website]. <b><u><a href=\"https:\/\/theredwoodliverstudy.com\/de-de?utm_source=Takeda&amp;utm_medium=StudyBrochure&amp;utm_campaign=GermanyPatientDay\">here<\/a>.<\/u><\/b><\/li>\n<li><a href=\"https:\/\/alpha1-deutschland.org\/en\/neue-beobachtungsstudie-von-csl-behring-fuer-patienten-in-heimselbsttherapie\/\">New observational study by CSL Behring for patients in home self-therapy<\/a><\/li>\n<li><a href=\"https:\/\/alpha1-deutschland.org\/en\/studienaufruf\/\" target=\"_blank\" rel=\"noopener\">Trainability of physical performance in COPD patients with alpha-1 antitrypsin deficiency \u2013 study participants wanted<\/a><\/li>\n<li><a href=\"https:\/\/alpha1-deutschland.org\/en\/studienteilnehmer-gesucht\/\">Patients with repeatedly elevated liver enzyme levels and\/or other indications of liver disease are being sought!<\/a><\/li>\n<li><a href=\"https:\/\/www.eurordis.org\/voices\" target=\"_blank\" rel=\"noopener noreferrer\">Opportunity to participate in various studies on rare diseases<\/a><\/li>\n<li><a href=\"https:\/\/www.clinicaltrialsarena.com\/news\/arrowhead-trial-rnai-therapeutic\/\" target=\"_blank\" rel=\"noopener noreferrer\">Arrowhead Pharmaceuticals administers ARO-AAT to first patient in SEQUOIA Phase 2\/3 trial for the treatment of Alpha-1 liver disease<\/a><\/li>\n<\/ul>\n <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"img-with-aniamtion-wrap\" data-max-width=\"100%\" data-max-width-mobile=\"default\" data-shadow=\"none\" data-animation=\"fade-in\" >\n      <div class=\"inner\">\n        <div class=\"hover-wrap\" data-hover-animation=\"zoom-crop\"> \n          <div class=\"hover-wrap-inner\">\n            <img loading=\"lazy\" decoding=\"async\" class=\"img-with-animation skip-lazy\" data-delay=\"0\" height=\"820\" width=\"1240\" data-animation=\"fade-in\" src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1.jpg\" alt=\"Teilnahme an einer Umfrage\" srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1.jpg 1240w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1-300x198.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1-1024x677.jpg 1024w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1-768x508.jpg 768w\" sizes=\"auto, (max-width: 1240px) 100vw, 1240px\" \/>\n          <\/div>\n        <\/div>\n        \n      <\/div>\n    <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n<\/div><\/div>\n\t\t\t<\/div> \n\t\t\t<div id=\"tab-durchgefuehrte-studien\" role=\"tabpanel\" aria-labelledby=\"tab-title-durchgefuehrte-studien\" tabindex=\"0\" data-tab-icon=\"iconsmind-Information\" class=\"wpb_tab ui-tabs-panel wpb_ui-tabs-hide clearfix\"><span class=\"im-icon-wrap tab-icon\"><span><svg role=\"presentation\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\">\n        <path d=\"M18.007 24.028h-4c-0.368 0-0.667-0.3-0.667-0.667v-9.333c0-0.367 0.299-0.667 0.667-0.667h4c0.368 0 0.667 0.3 0.667 0.667v9.333c0 0.368-0.299 0.667-0.667 0.667zM14.673 22.695h2.667v-8h-2.667v8zM16.007 12.073c-1.475 0-2.675-1.197-2.675-2.675s1.2-2.675 2.675-2.675c1.475 0 2.675 1.197 2.675 2.675s-1.2 2.675-2.675 2.675zM16.007 8.057c-0.74 0-1.341 0.601-1.341 1.341s0.601 1.341 1.341 1.341c0.741 0 1.341-0.601 1.341-1.341s-0.6-1.341-1.341-1.341zM16 32c-8.823 0-16-7.177-16-16s7.177-16 16-16 16 7.177 16 16-7.177 16-16 16zM16 1.333c-8.087 0-14.667 6.583-14.667 14.667 0 8.087 6.58 14.667 14.667 14.667 8.085 0 14.667-6.58 14.667-14.667 0-8.085-6.579-14.667-14.667-14.667z\"><\/path>\n        <\/svg><\/span><\/span>\n\t\t\t\t<div id=\"fws_6a8f065e6f51b\" data-midnight=\"\" data-column-margin=\"90px\" class=\"wpb_row vc_row-fluid vc_row inner_row vc_row-o-equal-height vc_row-flex vc_row-o-content-middle\"  style=\"padding-top: 3%; padding-bottom: 3%; \"><div class=\"row-bg-wrap\"> <div class=\"row-bg\" ><\/div> <\/div><div class=\"row_col_wrap_12_inner col span_12  left\">\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"nectar-fancy-ul\" data-list-icon=\"fa fa-check\" data-animation=\"false\" data-animation-delay=\"0\" data-color=\"accent-color\" data-spacing=\"10px\" data-alignment=\"left\"> \n<ul>\n<li>\n<p style=\"font-weight: 400;\">A nationwide Danish study investigated whether people with alpha-1 antitrypsin deficiency have an increased risk of cancer. For this purpose, 2,702 people with alpha-1 were compared with 26,750 people without alpha-1. The results showed an increased risk of skin cancer (2.18-fold), leukemia (1.76-fold), and liver cancer (3.91-fold) in people with alpha-1. This increased risk of skin and liver cancer was also observed independently of the presence of certain comorbidities such as COPD, skin diseases, or liver cirrhosis. The study thus provides evidence of an association between alpha-1 antitrypsin deficiency and an increased risk of certain cancers. However, a causal relationship cannot be inferred from the results. Korsb\u00e6k NJ, Landt EM, Marott SCW et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39352697\/\" target=\"_blank\" rel=\"noopener\"><em>Alpha-1 antitrypsin deficiency associated with increased risks of skin cancer, leukemia, and hepatic cancer: A nationwide cohort study<\/em><\/a><em>.<\/em> Journal of Internal Medicine. 2024;296(6):460\u2013467.<\/p>\n<\/li>\n<li>Approximately 1 in 1,000 patients with alpha-1 antitrypsin deficiency suffers from panniculitis, an inflammation of the subcutaneous fat tissue. A new study with 41 participants compiles the results of a survey covering symptoms, diagnosis, finding a doctor, quality of life, and treatment. The authors believe significant improvements are needed in all four of these latter aspects. You can find the study here. <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0326686\">here<\/a>.<\/li>\n<li>\n<p style=\"font-weight: 400;\">New research findings from Heidelberg University Hospital, among others, challenge the previously prevailing view that emphysema in patients with alpha-1 antitrypsin deficiency (AATD) primarily manifests in the lower lobes of the lungs: refined computed tomography methods have demonstrated that, particularly in rare AATD mutations with mildly to moderately reduced serum AAT levels, emphysema also occurs, or is even more pronounced, in the higher lung regions. Under this <a href=\"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-025-03413-4\" target=\"_blank\" rel=\"noopener\">link<\/a> The full study is available for viewing.<\/p>\n<\/li>\n<li>A comprehensive study on the effects of COPD (including in patients with alpha-1 antitrypsin deficiency) was conducted under the name COSYCONET. A summary of the results can be found here. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9931494\/\">here<\/a><\/li>\n<li>The study <a href=\"https:\/\/www.resmedjournal.com\/article\/S0954-6111(23)00394-3\/abstract\">Impact of COPD on mortality: An 8-year observational retrospective healthcare claims database cohort study<\/a> Under the leadership of Prof. Vogelmeier, the article illustrates the impact of COPD on mortality risk and underscores the need for consistent COPD management, including the assessment and treatment of exacerbations. It also emphasizes the necessity of consistent use of prescribed medications.<\/li>\n<li>\n<p style=\"font-weight: 400;\"><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2401304\">Current Phase III study on Dupilumate<\/a> has confirmed the results of a previous study: Dupilumab, a monoclonal antibody, can reduce the exacerbation rate in COPD and improve lung function in some COPD patients (with type 2 inflammation with many eosinophils).<br \/>\nWith dupilumab, moderate and severe exacerbations decreased by 34 percent. Lung function (especially FEV1) also improved significantly.<\/p>\n<\/li>\n<li>A systematic literature review on rare variants of alpha-1 antitrypsin deficiency was presented in Orphanet J Rare Dis. 2024; 19: 82., Published online 2024 Feb 22. doi: 10.1186\/s13023-024-03069-1, PMCID: PMC10885523, PMID: 38388492.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10885523\/\">Rare variants in alpha 1 antitrypsin deficiency: a systematic literature review<\/a>\n<p style=\"font-weight: 400;\">The authors Ilaria Ferrarotti, Marion Wencker and Joanna Chorostowska-Wynimko show that AATD extends far beyond the Z and S variants, and the article again suggests that patients with this disease are frequently underdiagnosed.<\/p>\n<p style=\"font-weight: 400;\">Figure 2, which shows the variants reported in Europe, is particularly noteworthy. Each geographical region has its own characteristic diversity of AATD variants. Therefore, comprehensive testing is needed to fully understand the actual number and nature of the variants present. Comprehensive testing is also necessary to ensure accurate diagnosis, optimize treatment strategies, and improve outcomes for patients with AATD.<\/p>\n<p><strong>\u00a0<\/strong><\/li>\n<li>In a study published in 1999 from Sweden on patients with chronic liver disease entitled <span lang=\"EN-GB\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10576378\/\"><span lang=\"DE\">The prevalence of gallstones in chronic liver disease is related to degree of liver dysfunction<\/span><\/a><\/span>\u00a0 It was found that carriers of the PI*MZ allele had a five times higher incidence of gallstones than non-carriers. The authors merely conclude that the risk of gallstones is increased in MZ carriers, but make no statements about a possible mechanism of gallstone formation.<\/li>\n<li>The study\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-018-07460-y\">Genome-wide association meta-analysis yields 20 loci associated with gallstone disease<\/a> A 2018 study analyzing over 27,000 cases of gallstones in biobanks from Iceland and the United Kingdom demonstrated that the risk of developing gallstones is significantly higher in individuals with alpha-1 antitrypsin deficiency (AATD) of the PI*MZ type than in those without this gene mutation. The authors hypothesize that the accumulation of AAT in liver cells leads to liver dysfunction, which predisposes individuals to gallstones.<\/li>\n<li><a href=\"https:\/\/www.researchgate.net\/publication\/340948874_Systemic_modified_messenger_RNA_for_replacement_therapy_in_alpha_1-antitrypsin_deficiency\" target=\"_blank\" rel=\"noopener\">The article &quot;Systemic Modified Messenger RNA as Replacement Therapy for Alpha-1 Antitrypsin Deficiency&quot; was published on ResearchGate in 2020. Firstly, it demonstrated the delivery of mRNA to primary human hepatocytes in culture. Secondly, it showed that the delivered mRNA is correctly translated into AAT protein by the cellular machinery.<\/a><\/li>\n<li>The study, published in 2022 <b><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33632708\/\">Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency<\/a><\/b>It defines the phenotypes affecting the liver, gallbladder, and bile ducts in alpha-1 deficiency and indicates their susceptibility to, among other things, gallstones and liver tumors. This is intended to enable better counseling and monitoring of patients.<\/li>\n<li><a href=\"https:\/\/journal.copdfoundation.org\/jcopdf\/id\/1354\/Intraindividual-Variability-in-Serum-Alpha-1-Antitrypsin-Levels\" target=\"_blank\" rel=\"noopener\">An international study<\/a>, A study published in August 2021 by the COPD Foundation in the USA clarifies that serum levels are not always conclusive, as they can more than double during inflammation, infection, or injury, and people with PiMZ or PiMS can have serum levels similar to those of healthy individuals (PiMM). Therefore, the authors always recommend additional genetic testing in all suspected cases.<\/li>\n<li><a href=\"https:\/\/alpha1-deutschland.org\/en\/alpha-1-antitrypsin-aktuelle-forschungsergebnisse\/\">Alpha-1 antitrypsin: Current research findings<\/a>, Prof. Sabina Janciauskiene<\/li>\n<li>In March 2021, a 19-item survey was sent to 420 patients with AATD who were being treated with AAT replacement therapy (Prolastin) and participating in the German AlphaCare patient program. Results were published in the journal Pneumologie on June 20, 2022:\u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35724679\/\" target=\"_blank\" rel=\"noopener\">Impact of the COVID-19 pandemic on information management and adherence to AAT replacement therapy in patients with alpha-1 antitrypsin deficiency (AATD)<\/a>\u201cAuthors: Thomas K\u00f6hnlein, Marion Wilkens, Katharina Eydt<\/li>\n<li>Comparative biochemical efficacy analysis of an alpha-1 proteinase inhibitor (Glassia\u00ae) in patients with alpha-1 antitrypsin deficiency, taking 45 minutes. The process is painless and requires only a small prick, just like a regular blood draw. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1094553922000153\" target=\"_blank\" rel=\"noopener\">Published in Pulmonary Pharmacology &amp; Therapeutics, March 2022.<\/a><\/li>\n<li>Two augmentation therapies show similar efficacy in AATD. <a href=\"https:\/\/www.rarediseaseadvisor.com\/news\/aatd-news-briefs\/two-augmentation-therapies-show-similar-efficacy-aatd\/\" target=\"_blank\" rel=\"noopener\">Published in RareDiseaseAdvisor, April 2022.<\/a><\/li>\n<li>The University of Ulm discovers that alpha-1 antitrypsin weakens the coronavirus: <a href=\"https:\/\/www.uni-ulm.de\/home\/uni-aktuell\/article\/koerpereigenes-protein-schwaecht-coronavirusalpha-1-antitrypsin-hemmt-sars-cov-2-indem-es-virenhelfer-enzym-ausschaltet\/\" target=\"_blank\" rel=\"noopener\">University News \u2013 University of Ulm<\/a><\/li>\n<li><a href=\"https:\/\/www.biospace.com\/article\/vertex-kills-program-for-vx-814-to-treat-rare-liver-disease\/\" target=\"_blank\" rel=\"noopener\">Vertex Pharmaceuticals has announced<\/a>, that it is halting the study and ending the development of the drug based on early data from its Phase II trial of VX-814 in Alpha-1 Antitrypsin Deficiency (AATD).<\/li>\n<li>How vitamin D can reduce COPD symptoms (<a href=\"https:\/\/alpha1-deutschland.org\/en\/herbst-zeit-der-erkaeltungen-der-impfung-und-der-sehnsucht-nach-sonne\/\">See our newsletter 2\/2018<\/a>):\u00a0<a href=\"https:\/\/www.healthline.com\/health-news\/vitamin-d-deficiency-and-copd-lung-attacks?slot_pos=article_1&amp;utm_source=Sailthru+Email&amp;utm_medium=Email&amp;utm_campaign=copd&amp;utm_content=2019-02-19\" target=\"_blank\" rel=\"noopener noreferrer\">Experts\u00a0<span class=\"institution\">the Queen Mary University of London<\/span>\u00a0They find that vitamin D can alleviate the symptoms of lung disease, but first it should be ensured that one&#039;s own body needs more of the mineral due to a deficiency.<\/a>.(Note: The source is in English; the following online translator is recommended:)\u00a0<a href=\"https:\/\/www.deepl.com\/translator\" target=\"_blank\" rel=\"noopener noreferrer\">DeppL<\/a>).<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30680526\" target=\"_blank\" rel=\"noopener noreferrer\">Data from Sweden show that the prevalence of liver disease in adult PiZZ patients is 10%. Age over 50 years, male sex, repeated elevated liver enzymes, hepatitis, and the presence of diabetes mellitus are risk factors for the development of liver disease.<\/a>\u00a0(Note: The source is in English; the following online translator is recommended:)\u00a0<a href=\"https:\/\/www.deepl.com\/translator\" target=\"_blank\" rel=\"noopener noreferrer\">DeppL<\/a>).<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30612958\" target=\"_blank\" rel=\"noopener noreferrer\">A study in America also confirms the benefit of using FibroScan\u00ae to screen for significant liver fibrosis. Patients at increased risk of developing liver complications in the future are identified early and benefit from more precise monitoring.<\/a>\u00a0(Note: The source is in English; the following online translator is recommended:)\u00a0<a href=\"https:\/\/www.deepl.com\/translator\" target=\"_blank\" rel=\"noopener noreferrer\">DeppL<\/a>).<\/li>\n<li>High prevalence of \u03b1-1-antitrypsin heterozygosity in<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/01.mpg.0000243434.54958.21\"> Children with chronic liver disease<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/alpha1-deutschland.org\/en\/neuerung-im-bereich-inhalative-therapien\/\">Innovation in the field of inhalation therapies \u2013 Or: How can digital solutions support us in the treatment of respiratory diseases?<\/a><\/li>\n<\/ul>\n <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"img-with-aniamtion-wrap\" data-max-width=\"100%\" data-max-width-mobile=\"default\" data-shadow=\"none\" data-animation=\"fade-in\" >\n      <div class=\"inner\">\n        <div class=\"hover-wrap\" data-hover-animation=\"zoom-crop\"> \n          <div class=\"hover-wrap-inner\">\n            <img loading=\"lazy\" decoding=\"async\" class=\"img-with-animation skip-lazy\" data-delay=\"0\" height=\"820\" width=\"1240\" data-animation=\"fade-in\" src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Mikroskop.jpg\" alt=\"Mikroskop\" srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Mikroskop.jpg 1240w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Mikroskop-300x198.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Mikroskop-1024x677.jpg 1024w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Mikroskop-768x508.jpg 768w\" sizes=\"auto, (max-width: 1240px) 100vw, 1240px\" \/>\n          <\/div>\n        <\/div>\n        \n      <\/div>\n    <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n<\/div><\/div>\n\t\t\t<\/div> \n\t\t\t<div id=\"tab-unterstuetzung-von-forschungen\" role=\"tabpanel\" aria-labelledby=\"tab-title-unterstuetzung-von-forschungen\" tabindex=\"0\" data-tab-icon=\"iconsmind-Information\" class=\"wpb_tab ui-tabs-panel wpb_ui-tabs-hide clearfix\"><span class=\"im-icon-wrap tab-icon\"><span><svg role=\"presentation\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\">\n        <path d=\"M18.007 24.028h-4c-0.368 0-0.667-0.3-0.667-0.667v-9.333c0-0.367 0.299-0.667 0.667-0.667h4c0.368 0 0.667 0.3 0.667 0.667v9.333c0 0.368-0.299 0.667-0.667 0.667zM14.673 22.695h2.667v-8h-2.667v8zM16.007 12.073c-1.475 0-2.675-1.197-2.675-2.675s1.2-2.675 2.675-2.675c1.475 0 2.675 1.197 2.675 2.675s-1.2 2.675-2.675 2.675zM16.007 8.057c-0.74 0-1.341 0.601-1.341 1.341s0.601 1.341 1.341 1.341c0.741 0 1.341-0.601 1.341-1.341s-0.6-1.341-1.341-1.341zM16 32c-8.823 0-16-7.177-16-16s7.177-16 16-16 16 7.177 16 16-7.177 16-16 16zM16 1.333c-8.087 0-14.667 6.583-14.667 14.667 0 8.087 6.58 14.667 14.667 14.667 8.085 0 14.667-6.58 14.667-14.667 0-8.085-6.579-14.667-14.667-14.667z\"><\/path>\n        <\/svg><\/span><\/span>\n\t\t\t\t<div id=\"fws_6a8f065e7364e\" data-midnight=\"\" data-column-margin=\"90px\" class=\"wpb_row vc_row-fluid vc_row inner_row vc_row-o-equal-height vc_row-flex vc_row-o-content-middle\"  style=\"padding-top: 3%; padding-bottom: 3%; \"><div class=\"row-bg-wrap\"> <div class=\"row-bg\" ><\/div> <\/div><div class=\"row_col_wrap_12_inner col span_12  left\">\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"nectar-fancy-ul\" data-list-icon=\"fa fa-check\" data-animation=\"false\" data-animation-delay=\"0\" data-color=\"accent-color\" data-spacing=\"10px\" data-alignment=\"left\"> The Alpha-1 Foundation in the USA continuously supports research into new therapies for Alpha-1 antitrypsin deficiency. <a href=\"https:\/\/alpha1.org\/grant-opportunities\/\">Here<\/a> Individuals and organizations can apply for research funding. <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"img-with-aniamtion-wrap\" data-max-width=\"100%\" data-max-width-mobile=\"default\" data-shadow=\"none\" data-animation=\"fade-in\" >\n      <div class=\"inner\">\n        <div class=\"hover-wrap\" data-hover-animation=\"zoom-crop\"> \n          <div class=\"hover-wrap-inner\">\n            <img loading=\"lazy\" decoding=\"async\" class=\"img-with-animation skip-lazy\" data-delay=\"0\" height=\"820\" width=\"1240\" data-animation=\"fade-in\" src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Labor.jpg\" alt=\"Frau im Labor\" srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Labor.jpg 1240w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Labor-300x198.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Labor-1024x677.jpg 1024w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Labor-768x508.jpg 768w\" sizes=\"auto, (max-width: 1240px) 100vw, 1240px\" \/>\n          <\/div>\n        <\/div>\n        \n      <\/div>\n    <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n<\/div><\/div>\n\t\t\t<\/div> \n\t\t\t<div id=\"tab-umfragen\" role=\"tabpanel\" aria-labelledby=\"tab-title-umfragen\" tabindex=\"0\" data-tab-icon=\"iconsmind-Information\" class=\"wpb_tab ui-tabs-panel wpb_ui-tabs-hide clearfix\"><span class=\"im-icon-wrap tab-icon\"><span><svg role=\"presentation\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\">\n        <path d=\"M18.007 24.028h-4c-0.368 0-0.667-0.3-0.667-0.667v-9.333c0-0.367 0.299-0.667 0.667-0.667h4c0.368 0 0.667 0.3 0.667 0.667v9.333c0 0.368-0.299 0.667-0.667 0.667zM14.673 22.695h2.667v-8h-2.667v8zM16.007 12.073c-1.475 0-2.675-1.197-2.675-2.675s1.2-2.675 2.675-2.675c1.475 0 2.675 1.197 2.675 2.675s-1.2 2.675-2.675 2.675zM16.007 8.057c-0.74 0-1.341 0.601-1.341 1.341s0.601 1.341 1.341 1.341c0.741 0 1.341-0.601 1.341-1.341s-0.6-1.341-1.341-1.341zM16 32c-8.823 0-16-7.177-16-16s7.177-16 16-16 16 7.177 16 16-7.177 16-16 16zM16 1.333c-8.087 0-14.667 6.583-14.667 14.667 0 8.087 6.58 14.667 14.667 14.667 8.085 0 14.667-6.58 14.667-14.667 0-8.085-6.579-14.667-14.667-14.667z\"><\/path>\n        <\/svg><\/span><\/span>\n\t\t\t\t<div id=\"fws_6a8f065e75965\" data-midnight=\"\" data-column-margin=\"90px\" class=\"wpb_row vc_row-fluid vc_row inner_row vc_row-o-equal-height vc_row-flex vc_row-o-content-middle\"  style=\"padding-top: 3%; padding-bottom: 3%; \"><div class=\"row-bg-wrap\"> <div class=\"row-bg\" ><\/div> <\/div><div class=\"row_col_wrap_12_inner col span_12  left\">\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"nectar-fancy-ul\" data-list-icon=\"fa fa-check\" data-animation=\"false\" data-animation-delay=\"0\" data-color=\"accent-color\" data-spacing=\"10px\" data-alignment=\"left\"> \n<ul>\n<li>Are you currently using oxygen therapy? Then your experience is needed: the survey is being conducted under the direction of Univ. Prof. Dr. Rembert Koczulla (Sch\u00f6n Klinik Berchtesgadener Land\/Philipps University Marburg). More information at [website address missing]. <a class=\"moz-txt-link-freetext\" href=\"https:\/\/alpha1-deutschland.org\/en\/aufruf-zur-patientenbefragung\/\" target=\"_blank\" rel=\"noopener\">https:\/\/alpha1-deutschland.org\/aufruf-zur-patientenbefragung<\/a><\/li>\n<li>\n<div class=\"field field--name-field-nir-news-title field--type-string field--label-hidden\">The research project \u201c is being conducted at the universities of Heidelberg and Mannheim.\u201c<a href=\"https:\/\/www.klinikum.uni-heidelberg.de\/new-lives-genomic-newborn-screening-programs\">NEW_LIVES<\/a>\u201dThe project, funded by the Federal Ministry of Education and Research (BMBF), includes an online survey on &quot;Genomic Newborn Screening&quot;.<\/div>\n<\/li>\n<li>\n<p style=\"font-weight: 400;\">Evaluations of the online survey for patients with non-tuberculous mycobacterial lung disease (NTM-LD) in Europe (ENPADE), European NTM lung disease Patient Disease Experience survey. <a href=\"https:\/\/ntmpatientsurvey.eu\/de\/\">Here are the survey results.<\/a><\/p>\n<\/li>\n<li>Are you having difficulty receiving your treatment? A survey by EURORDIS Rare Diseases Europe.\u00a0<a href=\"https:\/\/www.surveymonkey.com\/r\/PKD3BRN\" target=\"_blank\" rel=\"noopener noreferrer\">Click here to take the survey.<\/a><\/li>\n<li>Evaluation of the questionnaires on the topic\u00a0<strong>Health maintenance in individuals affected by Alpha-1<\/strong>\u00a0on the occasion of the 2018 general meeting in G\u00f6ttingen.\u00a0<a href=\"https:\/\/www.alpha1-deutschland.org\/wp-content\/uploads\/Umfrage.pdf\">The survey results are available for download.<\/a><\/li>\n<li>Evaluation of the questionnaires on the topic\u00a0<strong>Relatives of Alpha-1 patients<\/strong>\u00a0on the occasion of the 2017 general meeting in G\u00f6ttingen.\u00a0<a href=\"https:\/\/alpha1-deutschland.org\/en\/hilfe-fuer-angehoerige\/\">Here are the survey results.<\/a><\/li>\n<li>Evaluation of the questionnaires on the topic\u00a0<strong>Alpha1 Journal<\/strong>\u00a0on the occasion of the members&#039; meeting in Bremen in 2016.\u00a0<a href=\"https:\/\/alpha1-deutschland.org\/en\/ihre-meinung-ist-uns-wichtig\/\">Here are the survey results.<\/a><\/li>\n<\/ul>\n <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"img-with-aniamtion-wrap\" data-max-width=\"100%\" data-max-width-mobile=\"default\" data-shadow=\"none\" data-animation=\"fade-in\" >\n      <div class=\"inner\">\n        <div class=\"hover-wrap\" data-hover-animation=\"zoom-crop\"> \n          <div class=\"hover-wrap-inner\">\n            <img loading=\"lazy\" decoding=\"async\" class=\"img-with-animation skip-lazy\" data-delay=\"0\" height=\"820\" width=\"1240\" data-animation=\"fade-in\" src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1.jpg\" alt=\"Teilnahme an einer Umfrage\" srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1.jpg 1240w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1-300x198.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1-1024x677.jpg 1024w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1-768x508.jpg 768w\" sizes=\"auto, (max-width: 1240px) 100vw, 1240px\" \/>\n          <\/div>\n        <\/div>\n        \n      <\/div>\n    <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n<\/div><\/div>\n\t\t\t<\/div> \n\t\t\t<div id=\"tab-publikationen\" role=\"tabpanel\" aria-labelledby=\"tab-title-publikationen\" tabindex=\"0\" data-tab-icon=\"iconsmind-Information\" class=\"wpb_tab ui-tabs-panel wpb_ui-tabs-hide clearfix\"><span class=\"im-icon-wrap tab-icon\"><span><svg role=\"presentation\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewbox=\"0 0 32 32\">\n        <path d=\"M18.007 24.028h-4c-0.368 0-0.667-0.3-0.667-0.667v-9.333c0-0.367 0.299-0.667 0.667-0.667h4c0.368 0 0.667 0.3 0.667 0.667v9.333c0 0.368-0.299 0.667-0.667 0.667zM14.673 22.695h2.667v-8h-2.667v8zM16.007 12.073c-1.475 0-2.675-1.197-2.675-2.675s1.2-2.675 2.675-2.675c1.475 0 2.675 1.197 2.675 2.675s-1.2 2.675-2.675 2.675zM16.007 8.057c-0.74 0-1.341 0.601-1.341 1.341s0.601 1.341 1.341 1.341c0.741 0 1.341-0.601 1.341-1.341s-0.6-1.341-1.341-1.341zM16 32c-8.823 0-16-7.177-16-16s7.177-16 16-16 16 7.177 16 16-7.177 16-16 16zM16 1.333c-8.087 0-14.667 6.583-14.667 14.667 0 8.087 6.58 14.667 14.667 14.667 8.085 0 14.667-6.58 14.667-14.667 0-8.085-6.579-14.667-14.667-14.667z\"><\/path>\n        <\/svg><\/span><\/span>\n\t\t\t\t<div id=\"fws_6a8f065e786a3\" data-midnight=\"\" data-column-margin=\"90px\" class=\"wpb_row vc_row-fluid vc_row inner_row vc_row-o-equal-height vc_row-flex vc_row-o-content-middle\"  style=\"padding-top: 3%; padding-bottom: 3%; \"><div class=\"row-bg-wrap\"> <div class=\"row-bg\" ><\/div> <\/div><div class=\"row_col_wrap_12_inner col span_12  left\">\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"nectar-fancy-ul\" data-list-icon=\"fa fa-check\" data-animation=\"false\" data-animation-delay=\"0\" data-color=\"accent-color\" data-spacing=\"10px\" data-alignment=\"left\"> \n<ul>\n<li style=\"font-weight: 400;\">AATD in Turkey: Two studies examined patients with severe respiratory illnesses in major Turkish hospitals for alpha-1 antitrypsin deficiency (AATD), which was subsequently diagnosed in 4\u201351 TP3T of the cases studied. The Z and S mutations, which are most common in Central Europe, play a significantly lesser role in Turkish patients; the Mmalton mutation and other mutations that are rare elsewhere are dominant. The Z and Mmalton mutations do not differ in terms of symptom burden; see also the next report in this section. The prevalence of AATD in Turkey remains unknown, but the Black Sea coastal region appears to be more affected than the Mediterranean coast. The original studies can be found [here\/on the website]. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38046982\/\" target=\"_blank\" rel=\"noopener\">here<\/a> and <a href=\"https:\/\/www.dovepress.com\/alpha-1-antitrypsin-genotype-distribution-in-patients-with-emphysema-peer-reviewed-fulltext-article-COPD\" target=\"_blank\" rel=\"noopener\">here<\/a> (Editor&#039;s note: the results described are of course also relevant for people of Turkish origin living in Germany).<\/li>\n<li>\n<div><span lang=\"EN-GB\">Characterization of the Mmalton carrier&#039;s cohort within the EARCO (European Alpha-1 Antitrypsin Research Collaboration) registry:<\/span><\/div>\n<div><span lang=\"EN-GB\"> Only 2.8% of the Alpha-1 patients recorded in the EARCO registry have the genotype PI*Mmalton. \u00a0<\/span>A comparative analysis of the lung-related symptom burden in patients with this very rare genotype revealed that, in the homozygous form and in heterozygous combination with another critical variant such as PI*Z, it is similarly pronounced as in patients with the PI*ZZ variant. In combination with a less critical variant such as PI*S, the lung-related symptom burden is lower. There were no differences between the compared groups with regard to liver stiffness and liver enzyme levels in the blood. The authors conclude that genotype-adapted therapy management is necessary. You can find the original report here. <b><u><a href=\"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-025-03651-8.pdf\">here<\/a> <\/u><\/b>download.<\/div>\n<\/li>\n<li><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7642868\/#:~:text=Alpha-1%20antitrypsin%20deficiency%20(AATD,the%20risk%20of%20lung%20cancer.&amp;text=The%20lung%20cancer%20histological%20types,are%20squamous%20carcinoma%20and%20adenocarcinoma.\">Alpha-1 antitrypsin deficiency and risk and lung cancer: A systematic review. <\/a><\/strong>An analysis of six studies with a total of 4,038 lung cancer patients, published in November 2020, suggests that AATM may increase the risk of developing lung cancer, particularly the histological types squamous cell carcinoma and adenocarcinoma. Further studies are needed to confirm these findings. <a href=\"https:\/\/publications.ersnet.org\/content\/erj\/early\/2022\/03\/17\/1399300303200-2021?implicit-login=true%26289\">In the European Respiratory journal<\/a> In 2022, an article was published whose findings suggest that individuals with severe alpha-1 antitrypsin deficiency have an increased risk of developing liver cancer and other cancers compared to the general population.<\/li>\n<li><b><span lang=\"EN-US\"><a href=\"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-024-02879-y\">Risk of lung disease in the PI*SS genotype of alpha-1 antitrypsin: an EARCO research project<\/a><\/span><\/b><span lang=\"EN-US\"> shows the risk of lung disease in the PI*SS genotype. <\/span>The EARCO team concluded that, as expected, the risk of lung disease associated with the PI*SS genotype is significantly lower compared to PI*ZZ. In contrast, no significant differences were found between PI*SS and PI*SZ in the incidence of lung disease or in the parameters of lung function, exacerbations, dyspnea, or quality of life.<\/li>\n<li>An increasingly important field in medicine deals with gender differences. Thanks to Professor Trudzinski and Dr. Ers\u00f6z, a team has analyzed data from the EARCO registry and specifically searched for differences in alpha-1 antitrypsin deficiency. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0300289624002448\"><b><span lang=\"EN-US\">Sex Differences in Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry<\/span><\/b><\/a><span lang=\"EN-US\"> \u00a9 2024 The Author(s). Published by Elsevier Espa\u00f1a, SLU on behalf of SEPAR. <\/span>The results show clear differences.<\/li>\n<\/ul>\n <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"   data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"img-with-aniamtion-wrap\" data-max-width=\"100%\" data-max-width-mobile=\"default\" data-shadow=\"none\" data-animation=\"fade-in\" >\n      <div class=\"inner\">\n        <div class=\"hover-wrap\" data-hover-animation=\"zoom-crop\"> \n          <div class=\"hover-wrap-inner\">\n            <img loading=\"lazy\" decoding=\"async\" class=\"img-with-animation skip-lazy\" data-delay=\"0\" height=\"820\" width=\"1240\" data-animation=\"fade-in\" src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1.jpg\" alt=\"Teilnahme an einer Umfrage\" srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1.jpg 1240w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1-300x198.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1-1024x677.jpg 1024w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/Studien-1-768x508.jpg 768w\" sizes=\"auto, (max-width: 1240px) 100vw, 1240px\" \/>\n          <\/div>\n        <\/div>\n        \n      <\/div>\n    <\/div>\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n<\/div><\/div>\n\t\t\t<\/div> \n\t\t<\/div> \n\t<\/div> \n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n<\/div><\/div>","protected":false},"excerpt":{"rendered":"Author Marion Wilkens, published in Alpha1-Journal 1\/2025. Alpha-1 antitrypsin deficiency (AATD) is a rare, inherited disorder that can primarily affect the lungs and liver. Affected individuals often develop chronic obstructive pulmonary disease (COPD)...","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1488","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Forschung &amp; Studien - Ihr Online Portal f\u00fcr Mitglieder und Interessierte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/alpha1-deutschland.org\/en\/forschung-studien\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Forschung &amp; Studien - Ihr Online Portal f\u00fcr Mitglieder und Interessierte\" \/>\n<meta property=\"og:url\" content=\"https:\/\/alpha1-deutschland.org\/en\/forschung-studien\/\" \/>\n<meta property=\"og:site_name\" content=\"Ihr Online Portal f\u00fcr Mitglieder und Interessierte\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-17T17:01:44+00:00\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"16 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/alpha1-deutschland.org\\\/forschung-studien\",\"url\":\"https:\\\/\\\/alpha1-deutschland.org\\\/forschung-studien\",\"name\":\"Forschung & Studien - Ihr Online Portal f\u00fcr Mitglieder und Interessierte\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/alpha1-deutschland.org\\\/#website\"},\"datePublished\":\"2017-01-25T13:50:31+00:00\",\"dateModified\":\"2026-08-17T17:01:44+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/alpha1-deutschland.org\\\/forschung-studien#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/alpha1-deutschland.org\\\/forschung-studien\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/alpha1-deutschland.org\\\/forschung-studien#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/alpha1-deutschland.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Forschung &#038; 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