{"id":3300,"date":"2019-12-09T10:41:23","date_gmt":"2019-12-09T09:41:23","guid":{"rendered":"https:\/\/www.alpha1-deutschland.org\/?p=3300"},"modified":"2020-03-10T17:20:19","modified_gmt":"2020-03-10T16:20:19","slug":"studienteilnehmer-gesucht","status":"publish","type":"post","link":"https:\/\/alpha1-deutschland.org\/en\/studienteilnehmer-gesucht","title":{"rendered":"Study participants sought"},"content":{"rendered":"<div id=\"fws_6a8de28a5a0f5\"  data-column-margin=\"default\" data-midnight=\"dark\" data-top-percent=\"3%\"  class=\"wpb_row vc_row-fluid vc_row full-width-section\"  style=\"padding-top: calc(100vw * 0.03); padding-bottom: 0px; \"><div class=\"row-bg-wrap\" data-bg-animation=\"none\" data-bg-animation-delay=\"\" data-bg-overlay=\"false\"><div class=\"inner-wrap row-bg-layer\" ><div class=\"row-bg viewport-desktop\"  style=\"\"><\/div><\/div><\/div><div class=\"row_col_wrap_12 col span_12 dark left\">\n\t<div  class=\"vc_col-sm-12 wpb_column column_container vc_column_container col no-extra-padding\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t<div class=\"nectar-gradient-text\" data-direction=\"horizontal\" data-color=\"extra-color-gradient-2\" style=\"\"><h2>Study participants sought: Patients with repeatedly elevated liver enzyme levels and\/or other indications of liver disease<\/h2><\/div><div class=\"divider-wrap\" data-alignment=\"default\"><div style=\"height: 50px;\" class=\"divider\"><\/div><\/div><div class=\"vc_separator wpb_content_element vc_separator_align_center vc_sep_width_100 vc_sep_border_width_5 vc_sep_pos_align_center vc_sep_color_grey wpb_content_element vc_separator-has-text\" ><span class=\"vc_sep_holder vc_sep_holder_l\"><span class=\"vc_sep_line\"><\/span><\/span><h4>Author<\/h4><span class=\"vc_sep_holder vc_sep_holder_r\"><span class=\"vc_sep_line\"><\/span><\/span>\n<\/div>\n<div class=\"wpb_text_column wpb_content_element\" >\n\t<p><strong>Priv.-Doz. Dr. med. Pavel Strnad<\/strong> \u2013 Head of the Alpha1 Liver Center and Scientific Advisory Board Alpha1-Deutschland eV &amp;<br \/>\n<strong>Dr. med. Karim Hamesch<\/strong> \u2013 Coordinating Study Physician<\/p>\n<\/div>\n\n\n\n<div class=\"divider-wrap\" data-alignment=\"default\"><div style=\"margin-top: 25px; height: 5px; margin-bottom: 25px;\" data-width=\"100%\" data-animate=\"\" data-animation-delay=\"\" data-color=\"default\" class=\"divider-border\"><\/div><\/div>\n<div class=\"wpb_text_column wpb_content_element\" >\n\t<p>Dear members and interested parties,<\/p>\n<p>While previously only lung involvement in AAT deficiency could be therapeutically influenced, two studies are now being planned or are already in their initial phase, aiming to (co-)treat the effects of AAT deficiency on the liver. Both studies currently only include subjects with the PiZZ genotype.<\/p>\n<p>Firstly, a study by the company Arrowhead is currently underway, in which the production of AAT is suppressed using siRNA. By halting the production of this hepatotoxic protein, the liver should be relieved of stress for up to two years and allowed to regenerate. The therapy does not target the genetic material (i.e., the DNA); it only addresses short-lived copies of the DNA (the so-called mRNA).<\/p>\n<p>Secondly, a study by the company Vertex will begin in Germany in the coming months. This study aims to enable the secretion of the mutated AAT from liver cells into the bloodstream. For this purpose, participants will take one tablet daily for one month.<\/p>\n<p>As previously mentioned, the Arrowhead study offers a longer-term treatment whose effectiveness should be verified by a liver biopsy, while the Vertex study will primarily examine changes in AAT levels in the blood. Therefore, the Arrowhead study is seeking participants with primary liver involvement, whereas the Vertex study will include most PiZZ participants who have not yet received augmentation therapy.<\/p>\n<p>Should you have any further questions about the studies or require additional information, please feel free to contact us. We can be reached at the following telephone number: 0241-80 36606\/35324<\/p>\n<\/div>\n\n\n\n\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n<\/div><\/div>","protected":false},"excerpt":{"rendered":"Study participants sought: Patients with repeatedly elevated liver enzymes and\/or other indications of liver disease. Author: Priv.-Doz. Dr. med. Pavel Strnad \u2013 Head of the Alpha1 Liver Center and Scientific Advisory Board Alpha1-Deutschland eV &amp; Dr. med....","protected":false},"author":1,"featured_media":3603,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,39,40],"tags":[],"class_list":["post-3300","post","type-post","status-publish","format-standard","has-post-thumbnail","category-allgemein","category-alpha-1-leber","category-forschung-und-studien"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Teilnehmer gesucht f\u00fcr zwei Studien zur Therapie von Lebersch\u00e4den<\/title>\n<meta name=\"description\" content=\"F\u00fcr Arrowhead werden Probanden mit einer vordergr\u00fcndigen Leberbeteiligung gesucht, f\u00fcr die Studie der Firma Vertex PiZZ-Probanden.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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