{"id":7131,"date":"2025-11-18T17:37:08","date_gmt":"2025-11-18T16:37:08","guid":{"rendered":"https:\/\/alpha1-deutschland.org\/?p=7131"},"modified":"2026-04-20T15:03:51","modified_gmt":"2026-04-20T13:03:51","slug":"foerderpreis-2025","status":"publish","type":"post","link":"https:\/\/alpha1-deutschland.org\/en\/foerderpreis-2025","title":{"rendered":"New research on Alpha-1: Congratulations to Dr. Andreas Hoheisel for the 2025 research award!"},"content":{"rendered":"<div id=\"fws_6a8c441d66dbb\"  data-column-margin=\"default\" data-midnight=\"dark\"  class=\"wpb_row vc_row-fluid vc_row full-width-section\"  style=\"padding-top: 0px; padding-bottom: 50px; \"><div class=\"row-bg-wrap\" data-bg-animation=\"none\" data-bg-animation-delay=\"\" data-bg-overlay=\"false\"><div class=\"inner-wrap row-bg-layer\" ><div class=\"row-bg viewport-desktop\"  style=\"\"><\/div><\/div><\/div><div class=\"row_col_wrap_12 col span_12 dark left\">\n\t<div  class=\"vc_col-sm-12 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t<div class=\"vc_separator wpb_content_element vc_separator_align_center vc_sep_width_100 vc_sep_border_width_5 vc_sep_pos_align_center vc_sep_color_grey wpb_content_element vc_separator-has-text\" ><span class=\"vc_sep_holder vc_sep_holder_l\"><span class=\"vc_sep_line\"><\/span><\/span><h4>Author<\/h4><span class=\"vc_sep_holder vc_sep_holder_r\"><span class=\"vc_sep_line\"><\/span><\/span>\n<\/div>\n<div class=\"wpb_text_column wpb_content_element\" >\n\t<p style=\"font-weight: 400;\"><strong>Marion Wilkens, as appeared in <a href=\"https:\/\/alpha1-deutschland.org\/en\/alpha1-journal\/\">Alpha1 Journal 2\/2025<\/a>.<\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"divider-wrap\" data-alignment=\"default\"><div style=\"margin-top: 25px; height: 5px; margin-bottom: 25px;\" data-width=\"100%\" data-animate=\"\" data-animation-delay=\"\" data-color=\"default\" class=\"divider-border\"><\/div><\/div>\n<div class=\"wpb_text_column wpb_content_element\" >\n\t<p>The MDGP&#039;s 2025 Young Researcher Award was presented at the 27th Autumn Meeting of the Central German Society for Pneumology and Thoracic Surgery (MDGP), held from November 14th to 15th, 2025 in Magdeburg. One of the two awards was given to Dr. Andreas Hoheisel from Leipzig\/Freiburg (Breisgau) for a project on alpha-1 antitrypsin deficiency, which we are very pleased about.<\/p>\n<p><strong>Project title: Non-targeted screening for alpha-1 antitrypsin deficiency<\/strong><\/p>\n<p>A first publication on this topic, co-authored with PD Dr. med. Thomas K\u00f6hnlein and Prof. Dr. Daiana Stolz, was already published in <a href=\"https:\/\/publications.ersnet.org\/content\/erj\/64\/suppl68\/pa366\" target=\"_blank\" rel=\"noopener\">European Respiratory Journal 2024 <\/a>instead of:<\/p>\n<p>This retrospective study examines a non-targeted screening of patients referred to sleep medicine and allergy practices. It investigates the prevalence of alpha-1 antitrypsin deficiency in patients referred for various reasons, even without respiratory symptoms. The aim was to determine whether individuals with this genetic deficiency can remain healthy into old age and do not necessarily develop symptoms.<\/p>\n<p>All participants underwent routine blood tests to determine their alpha-1 antitrypsin levels, regardless of whether they presented with respiratory conditions such as cough or shortness of breath, or with other complaints such as allergies or suspected sleep apnea. A total of 5,325 individuals were examined, approximately half for respiratory conditions and the other half for non-respiratory problems. Forty individuals, less than one percent of those examined, showed significantly reduced alpha-1 antitrypsin levels, indicating a severe genetic deficiency. These patients were between 27 and 88 years old, and the most frequent genetic finding corresponded to a severe deficiency type. Liver function was almost always normal; only one individual developed symptoms before the age of 40. From the age of 40 onward, approximately half of the affected individuals exhibited lung disease, which manifested itself with declining lung function with increasing age. Many affected individuals, however, had no or only mild symptoms, despite having the genetic defect. More than half had smoked at some point in their lives, yet only a portion of them developed lung disease.<\/p>\n<p>The results show that alpha-1 antitrypsin deficiency can manifest very differently and does not automatically lead to illness, even in old age. These are encouraging results that now support our long-held belief that &quot;a deficiency is not necessarily an illness&quot; with data.<\/p>\n<p>Since we were in Berlin together when Dr. Hoheisel received the news, we were able to congratulate him personally and pledge and discuss our cooperation for further Alpha-1 projects.<\/p>\n<\/div>\n\n\n\n\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n<\/div><\/div>\n\t\t<div id=\"fws_6a8c441d688f2\"  data-column-margin=\"default\" data-midnight=\"dark\"  class=\"wpb_row vc_row-fluid vc_row\"  style=\"padding-top: 0px; padding-bottom: 0px; \"><div class=\"row-bg-wrap\" data-bg-animation=\"none\" data-bg-animation-delay=\"\" data-bg-overlay=\"false\"><div class=\"inner-wrap row-bg-layer\" ><div class=\"row-bg viewport-desktop\"  style=\"\"><\/div><\/div><\/div><div class=\"row_col_wrap_12 col span_12 dark left\">\n\t<div  class=\"vc_col-sm-12 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t<div class=\"divider-wrap\" data-alignment=\"center\"><div style=\"margin-top: 25px; width: 20%; height: 2px; margin-bottom: 25px;\" data-width=\"20%\" data-animate=\"\" data-animation-delay=\"\" data-color=\"accent-color\" class=\"divider-small-border\"><\/div><\/div><div class=\"img-with-aniamtion-wrap center\" data-max-width=\"100%\" data-max-width-mobile=\"default\" data-shadow=\"none\" data-animation=\"none\" >\n      <div class=\"inner\">\n        <div class=\"hover-wrap\"> \n          <div class=\"hover-wrap-inner\">\n            <img loading=\"lazy\" decoding=\"async\" class=\"img-with-animation skip-lazy\" data-delay=\"0\" height=\"602\" width=\"800\" data-animation=\"none\" src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/forschung-hoheisel2.jpg\" alt=\"Drei Personen von denen sich zwei die H\u00e4nde sch\u00fctteln.\" srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/forschung-hoheisel2.jpg 800w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/forschung-hoheisel2-300x226.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/forschung-hoheisel2-768x578.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/>\n          <\/div>\n        <\/div>\n        \n      <\/div>\n    <\/div><div class=\"divider-wrap\" data-alignment=\"center\"><div style=\"margin-top: 25px; width: 20%; height: 2px; margin-bottom: 25px;\" data-width=\"20%\" data-animate=\"\" data-animation-delay=\"\" data-color=\"accent-color\" class=\"divider-small-border\"><\/div><\/div>\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n<\/div><\/div>\n\t\t<div id=\"fws_6a8c441d6a59c\"  data-column-margin=\"default\" data-midnight=\"dark\"  class=\"wpb_row vc_row-fluid vc_row\"  style=\"padding-top: 0px; padding-bottom: 0px; \"><div class=\"row-bg-wrap\" data-bg-animation=\"none\" data-bg-animation-delay=\"\" data-bg-overlay=\"false\"><div class=\"inner-wrap row-bg-layer\" ><div class=\"row-bg viewport-desktop\"  style=\"\"><\/div><\/div><\/div><div class=\"row_col_wrap_12 col span_12 dark left\">\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t\n<div class=\"wpb_text_column wpb_content_element\" >\n\t<p>In 2026, we will report on the next research projects of Dr. Hoheisel, together with Prof. Dr. Stolz and PD Dr. K\u00f6hnlein. They are key players in the digital transformation of Alpha-1 deficiency research and are helping to advance research and improve care. To this end, they are using new technologies such as AI for the diagnosis and management of this important, yet often overlooked, genetic disorder.<\/p>\n<p>Congratulations, dear Dr. Hoheisel, and keep up the good work!<\/p>\n<\/div>\n\n\n\n\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n\n\t<div  class=\"vc_col-sm-6 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone flex_gap_desktop_10px\"  data-padding-pos=\"all\" data-has-bg-color=\"false\" data-bg-color=\"\" data-bg-opacity=\"1\" data-animation=\"\" data-delay=\"0\" >\n\t\t<div class=\"vc_column-inner\" >\n\t\t\t<div class=\"wpb_wrapper\">\n\t\t\t\t<div class=\"img-with-aniamtion-wrap\" data-max-width=\"100%\" data-max-width-mobile=\"default\" data-shadow=\"none\" data-animation=\"none\" >\n      <div class=\"inner\">\n        <div class=\"hover-wrap\"> \n          <div class=\"hover-wrap-inner\">\n            <img loading=\"lazy\" decoding=\"async\" class=\"img-with-animation skip-lazy\" data-delay=\"0\" height=\"450\" width=\"800\" data-animation=\"none\" src=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/forschung-hoheisel3.jpg\" alt=\"Portraitfotos von Herr PD. Dr. med. Thomas K\u00f6hnlein\" srcset=\"https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/forschung-hoheisel3.jpg 800w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/forschung-hoheisel3-300x169.jpg 300w, https:\/\/alpha1-deutschland.org\/wp-content\/uploads\/forschung-hoheisel3-768x432.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/>\n          <\/div>\n        <\/div>\n        \n      <\/div>\n    <\/div>\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n<\/div><\/div>","protected":false},"excerpt":{"rendered":"AutorIn Marion Wilkens, so erschienen im Alpha1-Journal 2\/2025. Der F\u00f6rderpreis 2025 der MDGP wurde anl\u00e4sslich der 27. Herbsttagung der Mitteldeutschen Gesellschaft f\u00fcr Pneumologie und Thoraxchirurgie e. V. vom 14. \u2013...","protected":false},"author":1,"featured_media":7132,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,24,42,40],"tags":[],"class_list":["post-7131","post","type-post","status-publish","format-standard","has-post-thumbnail","category-allgemein","category-alpha1-journal","category-aus-der-forschung","category-forschung-und-studien"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MDGP F\u00f6rderpreis 2025: Alpha-1-Screening Studie<\/title>\n<meta name=\"description\" content=\"Auszeichnung f\u00fcr Alpha-1-Forschung: Studie zeigt, dass ein Mangel oft symptomfrei bleibt. 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