There is still limited knowledge about the impact of severe alpha-1 antitrypsin deficiency in pregnant women. However, there is evidence suggesting that AAT plays a role in conception and pregnancy. Associations between low AAT levels and pregnancy-related complications such as preeclampsia, miscarriage, and premature birth have been described in the literature.
Because alpha-1 antitrypsin deficiency is often only discovered at an advanced age, many women have given birth to children without knowing about their genetic defect; a few report complications in retrospect.
Please discuss your alpha-1 antitrypsin deficiency and your pregnancy with your doctors. More frequent check-ups may be advisable.
The article „Pregnancy in Alpha-1 Antitrypsin (AAT) Deficiency and the Role of Intravenous AAT Therapy“ by G. Guarnieri, A. Achill, S. Lococo and A. Vianello addresses this topic and presents a case study:
To the article
An article by the authors Gaeckle, Stephanson and Reilkoff from 2020 also deals with the topic and attempts to interpret the few known data:
To the article
Another article deals with „Alpha-1-Antitrypsin Z variant (AAT PI*Z) as a risk factor for intrahepatic cholestasis of pregnancy“ and was written by doctors and researchers from Poland:
To the article
